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Buy nembutal powder now (pentobarbital sodium) is a barbiturate that acts as a depressant, or sedative, used short-term to treat insomnia. Nembutal is also used as an emergency treatment for seizures, and to cause patients to fall asleep for surgery. Buy Nembutal powder now is available in generic form.

What are side effects of Nembutal?

Common side effects of Nembutal include:

  • problems with memory or concentration,
  • excitement,
  • irritability,
  • aggression (especially in children or older adults),
  • confusion,
  • loss of balance or coordination,
  • nightmares,
  • nausea,
  • vomiting,
  • constipation,
  • headache,
  • drowsiness,
  • “hangover” effect (drowsiness the day after a dose),
  • agitation,
  • nervousness,
  • insomnia,
  • anxiety,
  • dizziness,
  • low blood pressure,
  • injection site reactions, or
  • skin rash.

Seek medical attention immediately if you suffer from any serious side effects of Nembutal such as: Buy nembutal powder

  • hallucinations,
  • weak or shallow breathing,
  • slow heart rate,
  • weak pulse, or
  • feeling like you might pass out.

DO NOT USE IF MATERIAL HAS PRECIPITATED

DESCRIPTION

The barbiturates are nonselective central nervous system depressants which are primarily used as sedative hypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are subject to control under the Federal Controlled Substances Act (See “Drug Abuse and Dependence” section).

The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions.

Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has no central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.

NEMBUTAL Sodium Solution (pentobarbital sodium injection) is a sterile solution for intravenous or intramuscular injection. Each mL contains pentobarbital sodium 50 mg, in a vehicle of propylene glycol, 40%, alcohol, 10% and water for injection, to volume. The pH is adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide.

NEMBUTAL (pentobarbital) Sodium is a short-acting barbiturate, chemically designated as sodium 5-ethyl-5-(1-methylbutyl) barbiturate. The structural formula for pentobarbital sodium is:

 

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The sodium salt occurs as a white, slightly bitter powder which is freely soluble in water and alcohol but practically insoluble in benzene and ether.

Parenteral

  1. Sedatives.
  2. Hypnotics, for the short-term treatment of insomnia, since they appear to lose their effectiveness for sleep induction and sleep maintenance after 2 weeks (See “CLINICAL PHARMACOLOGY” section.)
  3. Preanesthetics.
  4. Anticonvulsant, in anesthetic doses, in the emergency control of certain acute convulsive episodes, e.g., those associated with status epilepticus, cholera, eclampsia, meningitis, tetanus, and toxic reactions to strychnine or local anesthetics.

DOSAGE AND ADMINISTRATION

Dosages of barbiturates must be individualized with full knowledge of their particular characteristics and recommended rate of administration.Buy nembutal powder Factors of consideration are the patient’s age, weight, and condition. Parenteral routes should be used only when oral administration is impossible or impractical.

Intramuscular Administration

IM injection of the sodium salts of barbiturates should be made deeply into a large muscle, and a volume of 5 mL should not be exceeded at any one site because of possible tissue irritation. After IM injection of a hypnotic dose, the patient’s vital signs should be monitored. The usual adult dosage of NEMBUTAL Sodium Solution is 150 to 200 mg as a single IM injection; the recommended pediatric dosage ranges from 2 to 6 mg/kg as a single IM injection not to exceed 100 mg.

Intravenous Administration

NEMBUTAL Sodium Solution should not be admixed with any other medication or solution. IV injection is restricted to conditions in which other routes are not feasible, either because the patient is unconscious (as in cerebral hemorrhage, eclampsia, or status epilepticus), or because the patient resists (as in delirium), or because prompt action is imperative.Buy nembutal powder Slow IV injection is essential, and patients should be carefully observed during administration. This requires that blood pressure, respiration, and cardiac function be maintained, vital signs be recorded, and equipment for resuscitation and artificial ventilation be available. The rate of IV injection should not exceed 50 mg/min for pentobarbital sodium.

There is no average intravenous dose of NEMBUTAL Sodium Solution (pentobarbital sodium injection) that can be relied on to produce similar effects in different patients. The possibility of overdose and respiratory depression is remote when the drug is injected slowly in fractional doses.

A commonly used initial dose for the 70 kg adult is 100 mg. Proportional reduction in dosage should be made for pediatric or debilitated patients. At least one minute is necessary to determine the full effect of intravenous pentobarbital. If necessary,Buy nembutal powder additional small increments of the drug may be given up to a total of from 200 to 500 mg for normal adults.

Anticonvulsant Use

In convulsive states,Buy nembutal powder dosage of NEMBUTAL Sodium Solution should be kept to a minimum to avoid compounding the depression which may follow convulsions. Buy nembutal powder The injection must be made slowly with due regard to the time required for the drug to penetrate the blood-brain barrier.

Special Patient Population

Dosage should be reduced in the elderly or debilitated because these patients may be more sensitive to barbiturates. Dosage should be reduced for patients with impaired renal function or hepatic disease.

Inspection

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration,Buy nembutal powder whenever solution containers permit. Solutions for injection showing evidence of precipitation should not be used.

HOW SUPPLIED

NEMBUTAL Sodium Solution (pentobarbital sodium injection, USP) is available in the following sizes:

20-mL multiple-dose vial, 1 g per vial (NDC 76478-501-20); and 50-mL multiple-dose vial, 2.5 g per vial (NDC 76478-501-50).

Each mL contains:

Pentobarbital Sodium, derivative of barbituric acid – 50 mg
Propylene glycol – 40% v/v
Alcohol – 10%
Water for Injection – qs
(pH adjusted to approximately 9.5 with hydrochloric acid and/or sodium hydroxide.)

Vial stoppers are latex free.

Exposure of pharmaceutical products to heat should be minimized. Avoid excessive heat. Protect from freezing.Buy nembutal powder It is recommended that the product be stored at 20° to 25°C (68° to 77°F), however, brief excursions are permitted between 15° to 30°C (59° to 86°F). See USP controlled room temperature.

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